Electrophoretographic Analysis of Blood-brain Barrier Function

P45: The Role of Blood-Brain Barrier Breakdown Following Traumatic Brain in Post-Traumatic Epilepsy

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Intensification of brain injury and blood-brain barrier permeability by short-term hypertension in experimental model of brain ischemia/reperfusion

Introduction: Arterial hypertension is one of the causes of stroke, and as one of the vasculotoxic conditions intensifies ischemic stroke complications. The aim of the present study was to analyze the effects of short-term cerebral hypertension on ischemia/reperfusion injury and pathogenesis of ischemic stroke. Methods: The experiments were performed on three groups of rats (N=36) Sham, cont...

Structure and function of the blood-brain barrier.

Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid barrier. The BBB at the level of brain microvessel endothelium is the major site of blood-CNS exchange. The structure and function of the BBB is summa...

Double function of MFSD2A transporter at the blood-brain barrier.

Blood Brain Barrier Permeation

The large surface area and the short diffusion distance from capillaries of the blood brain barrier (BBB) to the neurons facilitate the drugs and nutrients access to the brain. Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. Tight junctions regulate the intracellular passage of molecules according to their physicochemical properties (e.g. lipo...